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本实验发现大鼠体表面积20％Ⅲ°烧伤后,皮肤内产生了大量丙二醛(MDA),第二天达最高,第七天有第二高峰,血浆和红细胞(RBC)MDA第三天达最高,血浆和RBC维生素E(VE)于伤后第二天后迅速下降,RBC溶血第三天最甚。对皮肤MDA、血浆MDA、RBCMDA、血浆VE、BBC VE、1％H_2O_2溶血进行相关分析后发现在不同时相,有不同的相关关系,但基本遵循烧伤皮肤MDA增加、血浆MDA增加、RBC MDA增加、血浆和RBC VE降低,溶血增加的规律。文中讨论了RBC损伤的机制。
In the present study, a large amount of malondialdehyde (MDA) was produced in the skin after 20% body surface area burns of 3 °, reaching the highest on the second day, the second peak on the seventh day and MDA on the third day of the plasma and red blood cell (RBC) The highest, plasma and RBC vitamin E (VE) decreased rapidly the day after injury, RBC hemolysis the third day the worst. Correlation analysis of skin MDA, RBCMDA, plasma VE, BBC VE, 1% H 2 O 2 hemolysis found that there were different correlations at different time phases, but basically follow the increase of MDA, increase of plasma MDA and increase of RBC MDA in burn skin , Plasma and RBC VE decreased hemolysis increased law. The mechanism of RBC injury is discussed in this article.