抗T淋巴细胞单克隆抗体治疗苯中毒致再生障碍性贫血

• 作 者: 王鲁群 迟翠芳 张明珙 宋素芹 孔凡盛 黄宁 刘希民 李嵋 张东红 周兰月
• 机 构: 济南军区总医院血液病科,山东医科大学附属医院血液病研究室
• 出 处: 山东医科大学学报
• 发表日期: 1999年01期
• 关键词: 再生障碍性贫血 单克隆抗体治疗 抗原表达 免疫调节治疗 细胞免疫 血细胞减少 基本治愈 毒副作用 再障 康力龙

为探讨免疫调节疗法对苯中毒所致再生障碍性贫血（ＡＡ）的疗效，采用抗人Ｔ淋巴细胞单克隆抗体（ＭｃＡｂＴ）ＳＭＵ３（抗ＣＤ３）和ＳＭＵ８（抗ＣＤ８）治疗８例苯中毒所致ＡＡ，基本治愈４例，缓解１例，明显进步３例。治疗前ＣＤ＋４／ＣＤ＋８比例倒置，淋巴细胞表面ＨＬＡＤＲ抗原表达增高；治疗后ＣＤ＋４／ＣＤ＋８比例及ＨＬＡＤＲ抗原表达恢复正常。无血清病及血细胞减少等严重毒副作用。证明苯中毒所致ＡＡ存在细胞免疫功能紊乱，ＭｃＡｂＴ免疫调节治疗具有显著疗效

To investigate the therapeutic effect of immunomodulatory therapy on aplastic anemia (AA) caused by benzene poisoning, eight cases of benzene poisoning were treated with anti-human T lymphocyte monoclonal antibody (McAbT) SMU3 (antiCD3) and SMU8 (antiCD8) Due to AA, 4 cases were basically cured, 1 case relieved, and 3 cases obviously improved. Before treatment, the proportion of CD + 4 / CD + 8 was inverted and the expression of HLADR antigen on lymphocyte surface was increased. After treatment, the ratio of CD + 4 / CD + 8 and HLADR antigen returned to normal. Serum-free disease and cytopenias and other serious side effects. Proved benzene poisoning caused by cellular immune dysfunction AA, McAb T immunomodulatory therapy has a significant effect