Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B

• 作 者: Ji Chen Yan Wang Xue-Jie Wu Ju
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2010年48期
• 关键词: CHRONIC HEPATITIS B Pegylated INTERFERON Α-2B therapy IMMUNE response CYTOKINE C
• 基金项目: Supported by National Natural Science Foundation of China, No. 30771905,National Basic Research Program of China (973 Program), No. 2007CB512800,Mega-projects of Science Research, No. 008ZX10002-008,B

AIM:To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS:Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were i