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目的和方法：观察地氟醚和芬太尼+地氟醚麻醉诱导的特点及测定两者半数气管插管最低肺泡浓度(MACEI50。结果：两组麻醉诱导均很迅速，意识消失时间分别为2．4分钟和2．5分钟。迅速增加地氟醚浓度，地氟醚组引起咳嗽57％、喉痉挛50％及MAP、HR显著升高。相反，芬太尼组很少发生咳嗽和喉痉挛，MAP和HR升高不显著。地氟醚组的MACEI50值为1．9±0．3MAC,静注芬太尼后地氟醚的MACEI50值降至1．1±0．2MAC。结论：地氟醚麻醉诱导迅速，但气道刺激和心血管反应发生率高；芬太尼可显著减轻其气道刺激和心血管反应，并降低地氟醚的MACEI50。“,”Objective and Methods:The study was done to evaluate the effect of fentanyl on the induction characteristicsand MAC of desflurane during endotracheal intubation (MACEI50) in the patients anesthetized with desflurane(group D) ordesflurane plus fentanyl(group F). Results: Loss of consciousness was in 2.4 min (group D) and 2.5 min(group F) respec-tively. The rapid increase of desflurane concentration resulted in coughing( 57 % ), laryngospasm( 50 % ), and significant incre-ments of MAP and HR during gaseous induction. In contrast, coughing and laryngospasm were rare, and MAP and HR re-mained stable during fentanyl plus desflurane induction. MACEI50 was significantly reduced from 1.9MAC during gaseous in-duction to 1.1 MAC during fentanyl plus desflurane induction. Conclusion: Induction of anesthesia with desflurane is rapid,but associated with a high incidence of airway and cardiovascular stimuli during gaseous induction. Fentanly attenuates airwayand cardiovascular response to desflurane and produces a decrease in the MACEI50 of desflurane.