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丙戊酸钠(抗癫灵)是一种新型抗癫痫药,动物实验对各种类型惊厥都有对抗作用。作用机理未完全搞清,据现有资料归纳有以下五个方面: 1、能竞争性地抑制Υ-氨基丁酸转氨酶,从而提高脑中Υ-氨基丁酸的浓度。 2、能升高脑中甘氨酸的浓度。 3、通过置换作用使血清游离色氨酸浓度增高,后者透过血脑屏障使其在脑中的浓度也升高,从而使5-羟色胺生成加速。
Sodium valproate (anti-epileptic) is a new type of antiepileptic drugs, animal experiments against all types of seizures have antagonistic effect. The mechanism of action is not fully understood, according to available information summarized in the following five aspects: 1, can competitive inhibition of γ-aminobutyrate aminotransferase, thereby increasing the concentration of brain γ-aminobutyric acid. 2, can increase brain glycine concentration. 3, through the replacement of serum free tryptophan concentration increased, the latter through the blood-brain barrier so that its concentration in the brain also increased, so that the formation of serotonin accelerated.