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糖尿病肾病是糖尿病晚期严重并发症之一,其发病率与病程长和高血压密切相关。因此,在合理饮食控制血糖的基础上,有选择地应用降糖、降压药物是该病治疗的重要组成部分。 在降糖药的选择上,糖适平应列为首选药,因其作用温和,代谢完全,代谢产物95％经胆道系统后,从粪便中排出体外,仅5％的代谢产物在尿中排泄,对肝、肾功能无任何毒副作用,是治疗该病最为理想的药物。成人一般用量:30～120mg/d,分3决于餐前口服。其次,应选用美吡达,它口服安全,奏效快,降糖作用维持时间长,且体内半衰期较短,以失活的代谢产物迅速从尿中排出,故毒副作用甚微。对治疗该病疗效显著,用法用量:每日2.5～20mg,分3次于餐前口服。再次,达美康最宜用于Ⅱ型糖尿病的治疗,也适用于糖尿病肾病的早期治疗。糖尿病患者长期服用此药,对糖尿病肾病的发生可起到重要的预防作用。其用法为,80～160mg/次,1～2次/日。至于优降糖、D_(860)等磺酰脲类药物因主要经肝脏代谢,其代谢产物近50％由肾脏排泄,故不适用于该病的治疗。降糖灵体内吸收后以原型及代谢产物由尿中排出,并可促进糖的无氧酵解,易发生乳酸性酸中毒而
Diabetic nephropathy is one of the serious complications of late stage of diabetes. Its incidence is closely related to the long course of disease and hypertension. Therefore, in a reasonable diet based on the control of blood glucose, the selective use of hypoglycemic, antihypertensive drugs is an important part of the treatment of the disease. In the choice of hypoglycemic agents, sugar should be flat as the preferred drug, because of its mild, fully metabolized, 95% of metabolites through the biliary system, excreted from the excrement, only 5% of the metabolites excreted in the urine , The liver and kidney function without any side effects, is the most ideal drug for the treatment of the disease. Adult General dosage: 30 ~ 120mg / d, divided into 3 depends on the meal before oral administration. Second, it should be the United States Pida, its oral safety, effective, hypoglycemic effect to maintain a long time, and short half-life in vivo, with inactivated metabolites quickly excreted from the urine, so little side effects. The treatment of the disease significant effect, usage: Daily 2.5 ~ 20mg, 3 times in the pre-meal oral. Once again, Deltamecon is the most suitable for the treatment of type II diabetes, but also for the early treatment of diabetic nephropathy. Long-term use of this medicine for diabetic patients can play an important preventive role in the occurrence of diabetic nephropathy. Its usage is, 80 ~ 160mg / time, 1 ~ 2 times / day. As for glyburide, D_ (860) sulfonylureas and other sulfonylureas are mainly metabolized by the liver, the metabolites of nearly 50% excreted by the kidneys, it is not suitable for the treatment of the disease. Hypoglycemic body after absorption of the prototype and metabolites excreted from the urine, and can promote the anaerobic glycolysis of glycolysis, prone to lactic acidosis and