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目的:探讨抗生素联合氨溴索口服溶液在新生儿肺炎治疗中对于减少抗生素使用时间的影响。方法:将60例新生儿肺炎患儿随机分为两组,分别给予单纯抗生素治疗(对照组)及抗生素联合氨溴索口服溶液治疗(观察组),两组患儿各30例。对所有患儿应用不同抗生素种类间使用抗生素时间进行分析,同时对比两组经治疗后咳嗽、肺部罗音消失时间,体温恢复时间及抗生素使用时间。结果:所有患儿应用抗生素种类与抗生素使用时间差异无统计学意义(P>0.05),两组经治疗后咳嗽消失时间比较,观察组明显优于对照组,差异有统计学意义(t=5.810 1,P=0.000 0);两组罗音消失时间比较,观察组明显优于对照组,差异有统计学意义(t=4.667 4,P=0.000 0);两组体温恢复时间比较,观察组明显优于对照组,差异有统计学意义(t=4.473 7,P=0.000 0);两组抗生素使用时间比较,观察组明显优于对照组,差异有统计学意义(t=4.688 7,P=0.000 0)。结论:新生儿肺炎应用抗生素联合氨溴索口服溶液治疗可显著减少抗生素使用时间,临床值得推广使用。
Objective: To investigate the effect of antibiotic combined with ambroxol oral solution on the reduction of antibiotic use time in the treatment of neonatal pneumonia. Methods: Sixty neonates with neonatal pneumonia were randomly divided into two groups, treated with antibiotics alone and antibiotics combined with ambroxol orally (observation group), 30 cases in each group. All antibiotics were used to analyze antibiotic time between different antibiotic groups. At the same time, cough, pulmonary vocal disappearance time, body temperature recovery time and antibiotic use time were compared between the two groups. Results: There was no significant difference in antibiotic use time and antibiotic use time among all children (P> 0.05). The cough disappear time in both groups was significantly better than that in the control group (t = 5.810 1, P = 0.000 0). Compared the disappearance time of two rales, the observation group was significantly better than the control group, the difference was statistically significant (t = 4.667 4, P = 0.000 0); two groups of body temperature recovery time comparison, observation group (T = 4.473 7, P = 0.000 0). Compared with the control group, the observation group was significantly better than the control group, the difference was statistically significant (t = 4.688 7, P = 0.000 0). Conclusion: Neonatal pneumonia with antibiotics combined with ambroxol oral solution can significantly reduce the antibiotic use time, it is worth to promote the clinical use.