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应用酶免疫技术对118例慢性肝炎、肝硬化患者进行血清转化生长因子β1（TGFβ1）、Ⅰ、Ⅲ型胶原（Ⅰ－C、Ⅲ－C）含量测定，分析三者与肝功能指标间相关关系。结果表明，患者血清TGFβ、Ⅰ、Ⅲ型胶原含量均高于正常对照组，且随慢迁肝→慢活肝→肝硬化逐渐递增，组间差异显著。血清TGFβ1与Ⅰ－C、Ⅲ-C、谷丙转氨酶呈正相关，与白／球比值、血清总胆红素不相关。提示TGFβ1可能是一种很有前途的肝纤维化血清学标志物，与Ⅰ、Ⅲ型胶原的联合检测可能有重要的临床意义。
Serum TGF-β1 (TGFβ1), type I and type Ⅲ collagen (Ⅰ-C, Ⅲ-C) levels were measured in 118 patients with chronic hepatitis and cirrhosis by enzyme immunoassay. The correlation between them and the indexes of liver function was analyzed . The results showed that the serum levels of TGFβ, type Ⅰ and type Ⅲ collagen were significantly higher than those in the normal control group, and gradually increased from slow-moving liver → slow-moving liver → cirrhosis. There was significant difference between the two groups. Serum TGFβ1 and Ⅰ-C, Ⅲ-C, alanine aminotransferase was positively correlated with the white / ball ratio, serum total bilirubin is not related. These results suggest that TGFβ1 may be a promising serological marker of hepatic fibrosis. Combined detection of TGFβ1 and type Ⅲ collagen may have important clinical significance.