Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vit

• 作 者: MiaoChen Guang-JiWang YongDiao
• 机 构: JiangsuKeyLabofDrugMetabolismandPharmacokinetics,GeneTherapyLaboratory
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2005年26期
• 关键词: 病毒感染 干扰素-Γ 肝纤维化 病理机制 Adeno-associated virus Interferon-γ Hepatic stellate cell
• 基金项目: 国家科技攻关项目

AIM: To investigate the effects of adeno-associated virus (AAV) mediated expression of human interferon-γ for gene therapy in experimental hepatic fibrosisin vitro and in vivo.METHODS: We constructed the recombinant AAV encoding human INF-γ (rAAV- INF-γ)