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[目的]探讨急性大面积脑梗死患者多项血清因子水平的变化规律。[方法]选取2008年1月~2010年12月于本院进行治疗的42例急性大面积脑梗死患者为A组,同期的42例中小面积梗死患者为B组,42名健康人员为C组,后将A组、B组发病后1d及7d和C组的血清ICAM-1、TGF-β1、IL-8、IL-10及VEGF水平进行统计及比较。[结果]A组发病后1d及7d的血清ICAM-1、TGF-β1、IL-8、IL-10及VEGF水平均高于B组及C组,而B组高于C组,经比较,P﹤0.05或P﹤0.01,差异有统计学意义。[结论]急性大面积脑梗死患者多项血清因子水平变化规律较为明显,值得进一步研究探讨。
[Objective] To investigate the changes of serum factors in acute large area cerebral infarction. [Methods] Forty-two patients with acute large area cerebral infarction who were treated in our hospital from January 2008 to December 2010 were selected as group A. Group B consisted of 42 patients with small and medium size infarcts in the same period and 42 healthy persons were in group C The levels of serum ICAM-1, TGF-β1, IL-8, IL-10 and VEGF in group A and group B at 1 and 7 days after onset and in group C were compared and statistically analyzed. [Results] The serum levels of ICAM-1, TGF-β1, IL-8, IL-10 and VEGF in group A were significantly higher than those in group B and C on the 1st day and the 7th day after onset, P <0.05 or P <0.01, the difference was statistically significant. [Conclusion] The changes of multiple serum factor levels in patients with acute large area cerebral infarction are more obvious and worth further study.