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作者对22例过敏性哮喘病人长期吸入色甘酸钠2mg qid,丁地去炎松(Budesonide)0.1mg qid,观察症状、β_2激动剂的应用、肺功能和支气管高反应性的变化,分别以双标本随机双盲交叉法与安慰剂进行比较。全部病人均为过敏体质。凡重度呼吸道感染、妊娠、近期口服或注射激素以及不能配合测定和记录者均除外。FEV_1基础值均>50%预计值。气道高反应性是以组织胺激发使 FEV_1下降20%的浓度(PC_(20)组织胺),整个实验17周。单盲安慰剂2周后接着用2种药物各6周,在2种药物间加用单盲安慰剂3周.实验开始测定肺功能指数,停用支气管扩张剂8小时且停止激烈运动后,测定流速容量曲线3次,取最佳值。17周中每天记录有关症状并计分(0-5);记录早、晚的最大呼气流速(PEFR);测定 PC_(20)组织胺,组织胺激发试验中止30分钟之后,FEV_1需恢复至基础值的≥95%,再进行运动激发试验,踏车开始以3公里/h 速度,30秒钟之后,加快速度至心率达到年龄相关的最大预计心率(220+年龄)≥80%,持续6分钟,测定运动前及后1、3、6、9、12、15分钟通气量,FEV_1下降的百分数.实验在室温19±1℃,湿度在60±10%进行.结果用色甘酸钠和丁地去炎松治疗的患者,其早晚 PEFR 均比安慰剂组明显升高,两组药物治疗期
The author of 22 patients with allergic asthma chronic long-term inhalation of cromolyn sodium 2mg, Ding to the song of pine (Budesonide) 0.1mg qid, observe the symptoms, the application of β 2 agonists, pulmonary function and bronchial hyperresponsiveness changes, respectively, Randomized double-blind crossover specimens were compared with placebo. All patients are allergic. Patients with severe respiratory infections, pregnancy, recent oral or injectable hormones, and those who can not cooperate with the determination and recording are excluded. FEV_1 baseline values> 50% of predicted. Airway hyperresponsiveness was induced by histamine to reduce the FEV_1 concentration by 20% (PC_ (20) histamine) throughout the experiment for 17 weeks. Blind placebo followed by 2 drugs for 6 weeks, 2 drugs plus single-blind placebo for 3 weeks.Studies began to measure the lung function index, bronchodilator disabled 8 hours and stop intense exercise, Determination of flow rate capacity curve 3 times, take the best value. Symptoms and scores were recorded daily for 17 weeks (0-5); morning and evening maximum expiratory flow rate (PEFR) was recorded; PC_ (20) histamine, histamine challenge test was suspended 30 minutes, FEV_1 need to be restored to Baseline value ≥ 95%, then exercise challenge test, treadmill start at 3 km / h speed, after 30 seconds, speed up until the heart rate reaches the age-dependent maximum expected heart rate (220 + age) ≥80%, for 6 Minute, before and after exercise 1, 3, 6, 9, 12, 15 minutes ventilation, the percentage of FEV_1 decreased.Experiment at room temperature 19 ± 1 ℃, humidity at 60 ± 10% .Results with cromolyn sodium and butyl To patients with inflammatory psoriasis, PEFR sooner or later were significantly higher than placebo, two groups of drug treatment