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Survivin是新近发现的一种凋亡抑制基因,是凋亡抑制基因家族的成员。Survivin表达于胚胎发育时期,而在大部分正常及分化成熟的组织中不表达。Survivin也高表达于大部分的人类肿瘤组织,其在肿瘤组织中的表达与肿瘤的侵袭性、预后和复发密切相关。它的高表达使其在临床靶向治疗的研究受到越来越多的关注,以Survivin为靶点的反义核苷酸和RNA干扰在泌尿系肿瘤的研究,可能为泌尿系肿瘤的治疗提供新的方法。
Survivin is a recently discovered inhibitor of apoptosis that is a member of the apoptosis-suppressing gene family. Survivin is expressed during embryonic development and is not expressed in most normal and differentiated mature tissues. Survivin is also highly expressed in most human tumor tissues, and its expression in tumor tissues is closely related to tumor invasion, prognosis and recurrence. Its high expression has attracted more and more attention in the research of clinical targeted therapy. The study of antisense nucleotide and RNA interference targeting Survivin in urological tumors may provide the treatment of urological tumors New method