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口服普萘洛治疗婴幼儿血管瘤(IH)已被证明安全有效,其副作用包括睡眠障碍等。该文对普萘洛尔治疗过程中出现睡眠障碍导致治疗中断的部分患儿改用口服纳多洛尔治疗,并对该药的疗效及安全性进行评估。对三级儿童医院2008年7月-2013年3月间接受普萘洛尔治疗的97例IH患儿进行回顾分析。结果:9(9.3%)例患儿出现睡眠障碍,7例中断治疗,改服纳多洛尔,5(71%)例患儿症状缓解,1例4个月后再次出现睡眠障碍。结论:由于样本量过小,
Oral propranolol treatment of infantile hemangiomas (IH) has been shown to be safe and effective, with side effects including sleep disturbances and the like. In this paper, propranolol treatment of sleep disorders caused by interruption of treatment in some children switched to oral natalolol treatment, and the efficacy and safety of the drug evaluation. A retrospective analysis was performed on 97 IH children who were treated with propranolol between July 2008 and March 2013 in a tertiary care hospital. RESULTS: Nine (9.3%) of the children had sleep disorders, seven were discontinued and treated with nadolol, and five (71%) of the children had symptom relief and one of them had a sleep disorder 4 months later. Conclusion: Due to the small sample size,