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工业生产中的毒物,主要指化学性物质,通常称为工业毒物。据估计,人类癌症约有90％与化学因素有关。近十年来,化学物质的致癌问题,越来越引起人们的广泛注意,到目前为止已对6,000多种化学物质做过致癌实验,发现其中1,100多种对动物有致癌作用。但目前国际癌症研究中心(IARC)认为对人有致癌作用的化学物质仅有30余种。化学物质致癌的机理是十分复杂的,有着多种的理论,但都不很成熟。有人认为,致癌物接触机体后,通过一系列化学、生物化学的反应,生成一种具有强亲电子的化学物质,通常又叫终末致癌物。它与脱氧核糖核酸(DNA)的碱基相互作用而导致DNA的损伤,从而改变了DNA的正常特性和功能。DNA是细胞的遗传物质,起着基因作用,一旦在结构或功能上发生了变化,这种恶性信息就会通过细胞分裂,遗传下去,结果使细胞具有了某种无控制性生
Poison in industrial production, mainly refers to chemical substances, commonly referred to as industrial poison. It is estimated that about 90% of human cancers are related to chemical factors. Over the past decade, the carcinogenicity of chemical substances has drawn more and more attention. So far, carcinogenic tests have been done on more than 6,000 chemicals and over 1,100 of them have carcinogenic effects on animals. However, there are only about 30 kinds of chemicals that IARC believes are carcinogenic to humans. The mechanism of carcinogenic chemicals is very complex, with a variety of theories, but not very mature. Some people think that carcinogens contact with the body, through a series of chemical and biochemical reactions, generating a kind of strong electrophilic chemicals, usually called terminal carcinogens. It interacts with the base of DNA to cause DNA damage, which alters the normal properties and function of DNA. DNA is the genetic material of the cell, plays a gene role, once the structure or function has changed, this malignant information will be split through cells, inheritance, the result of cells with some uncontrolled sex