Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibrobla

• 作 者: WeiZHAO ZhongXiangLIN ZhiQianZ
• 机 构: PekingUniversitySchoolofOncology
• 出 处: 细胞研究：英文版
• 发表日期: 2004年1期
• 关键词: 顺氯氨铂 早期衰老 成纤维细胞 人类 细胞间通讯 联接蛋白 cisplatin premature senescence gap junction int
• 基金项目: National Key Program for Basic Research，国家自然科学基金，reference suggestion

To examine the role of gap junctions in cell senescence,the changes of gap junctions in cisplatin-induced premature senescence of primary cultured fibroblasts were studied and compared with the replicative senescent human fibroblasts.Dye transfer assay fo