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本文分析12例存活5年以上急性白血病之临床资料,4例儿童,8例成人;男7例,女5例;年龄4～67岁;ALL 6例,ANLL 6例。ALL以VP或VMP治疗,ANLL则以COAP,HOAP,CAMP等处理。体会:(1) 年龄与白血病类型不影响其长期生存。(2) 急白长期生存的有利因素为治疗前白细胞<3.5万,而Hb,血小板数,骨髓原始细胞数及肝、脾、淋巴结肿大并不影响存活期。(3) 强力联合化疗、坚持维持治疗是长期生存的关键。其他综合治疗如中医药治疗、预防感染及髓外白血病、免疫及支持疗法也很重要。(4) 本文1例于完全缓解7年后复发,提示:维持治疗时间宜延长至7年以上。
The clinical data of 12 patients with acute leukemia survived for more than 5 years were analyzed in this paper. There were 4 children and 8 adults. There were 7 males and 5 females, aged 4 to 67 years. ALL treated with VP or VMP, ANLL with COAP, HOAP, CAMP and other treatment. Experience: (1) Age and type of leukemia do not affect their long-term survival. (2) The favorable factors for long-term survival of acute white white blood cells before treatment <35000, and Hb, platelet count, bone marrow blast cell number and liver, spleen, lymph node enlargement does not affect the survival. (3) strong combination chemotherapy, adhere to the maintenance of treatment is the key to long-term survival. Other general treatments such as TCM treatment, prevention of infection and extramedullary leukemia, immunization and supportive care are also important. (4) 1 case of complete remission after 7 years of relapse, suggesting that: maintenance treatment should be extended to more than 7 years.