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AIM:To approach the relationship between alveolarechinococcosis (AE) pathology and level of sIL-2R,TNF-αand IFN-γ in sera and the significance of cytokines indevelopment of AE.METHODS:After 23 patients with AE were confirmed byELISA and ultrasound,their sera were collected and theconcentrations of sIL-2R,TNF-α and IFN-γ were detectedby double antibody sandwich.Twelve healthy adults servedas controls.According to the status of livers of AE patients byultrasound scanning,they were divided into 4 groups:P_2,P_3,P_4 groups and C group (control).Average of concentrationsof sIL-2R,TNF-α and IFN-γin homologous group was statisticallyanalyzed by both ANOV and Newman-Keuls,respectively.RESULTS:The mean of sIL-2R in P_2 group was 97±29,P_3:226±80,P_4:194±23 and control group (111±30)×10~3 u/L(P<0.01).The mean of TNF-α in P_2 group was 1.12±0.20,P_3:3.67±1.96,P_4:1.30±0.25 and control group 0.40±0.19 μg/L(P<0.01).The mean of IFN-γ in P_2 group was 360±20,P_3:486±15,P_4:259±19 and control group:16±2 ng/L (P<0.01).Judged by ANOV and Newman-Keuls,the mean concentrationsof sIL-2R,TNF-α and IFN-γ had a significant differenceamong groups.Except for P_2 group,the mean sIL-2R betweenother groups of AE patients had a significant difference(P<0.05).The mean of TNF-α concentration in P_3 groupwas the highest (P<0.01).The mean of IFN-γ concentrationin all patients was higher than that in control group (P<0.01),but there was no difference between AE groups (P>0.05).CONCLUSION:Low sIL-2R level indicates an early stage ofAE or stable status,per contra,a progression stage.Higherlevel of TNF-α might be related to the lesion of liver.Therote of single IFN-γ is limited in immunological defenseagainst AE and it can not fully block pathological progression.
AIM: To approach the relationship between alveolarechinococcosis (AE) pathology and level of sIL-2R, TNF-α and IFN-γ in sera and the significance of cytokines indevelopment of AE. METHODS: After 23 patients with AE who were confirmed by ELISA and ultrasound, their sera were collected and the concentrations of sIL-2R, TNF-α and IFN-γ were detected by double antibody sandwich.Twelve healthy adults servedas controls. According to the status of livers of AE patients byultrasound scanning, they were divided into 4 groups: P_2, P_3, P_4 groups and C group (control). Average of concentrations of sIL-2R, TNF-α and IFN-γin hom homologous group was statistically analyzed by both ANOV and Newman-Keuls, respectively.RESULTS: The mean of sIL-2R in P_2 group were 97 ± 29, P_3: 226 ± 80, P_4: 194 ± 23 and control group (111 ± 30) × 10 ~ 3 u / L , P_3: 3.67 ± 1.96, P_4: 1.30 ± 0.25 and control group 0.40 ± 0.19 μg / L (P <0.01). The mean of IFN-γ in P_2 group was 360 ± 20, P_3: 486 ± 15, P_4: 259 ± 19 and control group: 16 ± 2 ng / L (P <0.01). Judged by ANOV and Newman-Keuls, the mean concentrations of sIL-2R, TNF-α and IFN-γ had a significant difference in bulk groups. Mean sIL-2R between other groups of AE patients had a significant difference (P <0.05). The mean of TNF-α concentration in P_3 group was the highest (P <0.01). The mean of IFN-γ concentration in all patients was higher than that in control group (P <0.01), but there was no difference between AE groups (P> 0.05) .CONCLUSION: Low sIL-2R level indicates an early stage of AE or stable status, per contra, a progression stage. Height- α might be related to the lesion of liver. Ther book of single IFN-γ is limited in immunological defense and can not fully block pathological progression.