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目的:研究慢性脑供血不全患者高血压病病程与血浆溶血磷脂酸极性相似磷脂(AP)的相关性。方法:随机选择慢性脑供血不全患者97例和正常对照者79名,检测血浆AP、溶血磷脂酸(LPA)、血脂、血糖,脂蛋白和D-二聚体,进行相关分析。结果:慢性脑供血不全患者高血压病病程≥10年与病程<10年者相比,AP水平中等以上增高人数明显增多,OR=2.643,95%CI=1.136～6.146。AP与高血压病病程显著相关,β=0.28,P=0.006。LPA、血脂、血糖,脂蛋白、D-二聚体等与高血压病病程均不相关。结论:AP对诊断脑供血不全可能有重要临床价值。
Objective: To study the relationship between the duration of hypertension and plasma lysophosphatidic acid polarity similar phospholipid (AP) in patients with chronic cerebral insufficiency. Methods: A total of 97 patients with chronic cerebral insufficiency and 79 normal controls were randomly selected. Plasma AP, LPA, blood lipid, blood glucose, lipoprotein and D-dimer were measured and analyzed. Results: The patients with chronic cerebral insufficiency had hypertension more than 10 years and duration of <10 years. The number of patients with moderate or higher levels of AP increased significantly (OR = 2.643, 95% CI = 1.136 ~ 6.146). AP and hypertension course of a significant correlation, β = 0.28, P = 0.006. LPA, blood lipids, blood glucose, lipoprotein, D-dimer, and hypertension are not related to the course. Conclusion: AP may have important clinical value in the diagnosis of cerebral insufficiency.