非抗心律失常药物的致心律失常作用

• 作 者: 范存忠
• 机 构: 江苏省如皋市人民医院 226500
• 出 处: 中国医学文摘.内科学
• 发表日期: 2001年04期
• 关键词: 致心律失常作用 受体阻滞剂 阿司咪唑 房室交界区 房室传导阻滞 咪哩 心脏病者 镇静作用 频发室性早搏 延迟后除极

抗心律失常药物可以致心律失常已为大家所熟知。近年来文献报道许多非抗心律失常药物亦可引起心律失常。现就此作一概述。1 第二代抗组织胺药(H_1受体阻滞剂) 阿司咪唑由于无中枢镇静作用,作为常用的抗过敏药物广泛应用于临床,致心律失常报道较多。王小旺报告1例应用阿司咪哩10mg/d治疗皮肤湿疹3个月,加量至20 mg/d,二周后发生Q-T延长,尖端扭转性室性心动过速(Tdp)。章素萍、王晓霞,分别报道1例误服阿司咪唑200mg和700 mg于24小时内发生Q-T间期延长并Tdp。慕

Antiarrhythmic drugs can cause arrhythmia has been well-known. In recent years, many non-antiarrhythmic drugs have been reported in the literature to cause arrhythmias. This is an overview. A second-generation antihistamine (H_1 receptor blocker) Astemizole as central no sedative effect, as a commonly used anti-allergy drugs are widely used in clinical, caused by arrhythmia reported more. Wang Xiaowang report 1 case of Asimile 10mg / d treatment of skin eczema for 3 months, add to 20 mg / d, two weeks after the occurrence of Q-T extension, torsades de pointes tdp. Zhang Su-ping, Wang Xiaoxia, were reported in 1 case of oral administration of astemizole 200mg and 700 mg within 24 hours of occurrence of Q-T interval prolongation and Tdp. Mu