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目的：了解影响茶碱血药浓度的因素。方法：对我科３１２例住院患者的５７２次茶碱血药浓度监测结果进行回顾性分析。结果：有３２２个样本茶碱血药浓度低于１０ｍｇ／Ｌ，在有效血药浓度范围内（１０～２０ｍｇ／Ｌ）的有１７３个，高于２０ｍｇ／Ｌ的有７７个。利福平、特布他林降低茶碱的血药浓度，而环丙沙星、西咪替丁可提高茶碱的血药浓度；肺心病或肝硬化病人茶碱的血药浓度较支气管哮喘患者的高，吸烟病人的茶碱血药浓度偏低。结论：口服茶碱时，其血药浓度存在个体差异，疾病及药物相互作用也可影响茶碱血药浓度。
Objective: To understand the factors that affect the plasma concentration of theophylline. Methods: The results of 572 episodes of theophylline plasma concentrations monitored in 312 inpatients in our department were analyzed retrospectively. Results: There were 322 samples of theophylline serum concentration of less than 10mg / L, within the effective plasma concentration range (10 ~ 20mg / L) of 173, higher than 20mg / L of 77. Rifampicin and terbutaline decreased the blood concentration of theophylline, while ciprofloxacin and cimetidine increased the blood concentration of theophylline; the plasma concentrations of theophylline in patients with pulmonary heart disease or cirrhosis were significantly lower than those in bronchial asthma Patients with high, smokers of theophylline plasma concentration is low. Conclusion: There are individual differences in the plasma concentration of theophylline when taken orally. The disease and drug interactions may also affect the plasma concentration of theophylline.