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目的观察ERα、ERβ在结直肠癌的表达的临床意义。方法收集95例手术治疗结直肠癌标本,制作组织芯片,采用免疫组化法测定ERαERβ在癌组织、癌旁组织中的表达。结果癌组织ERα、ERβ的表达率为35.4%和78.0%。癌旁组织表达率9.5%和60.5%。癌组织ERβ的表达高于ERα(P<0.05),癌组织ERα的和ERβ的表达高于癌旁组织(P<0.05)且与病理分级相关(P<0.05)。结论 ERα的和ERβ在结直肠癌的发生发展中起一定作用。
Objective To observe the clinical significance of ERα and ERβ expression in colorectal cancer. Methods Colorectal cancer specimens were collected from 95 cases for surgical treatment. Tissue microarray was made and the expression of ERαERβ was detected by immunohistochemistry in cancer tissue and paracancerous tissues. Results The expression rates of ERα and ERβ in cancer tissues were 35.4% and 78.0%. The expression rate of paracancerous tissue was 9.5% and 60.5%. The expression of ERβ in cancerous tissues was higher than that in ERα (P <0.05). The expression of ERα and ERβ in cancerous tissues was significantly higher than that in paracancerous tissues (P <0.05) and correlated with pathological grade (P <0.05). Conclusion ERα and ERβ play a role in the development of colorectal cancer.