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目的探讨乌司他丁对烧伤脓毒症的治疗作用。方法40例烧伤脓毒症患者随机分为乌司他丁(UTI)治疗组和对照组,每组各20例,两组均经常规治疗,治疗组加用UTI治疗。测定两组确诊脓毒症时以及确定后第7天的MDA浓度和SOD活性,观察比较两组患者脓毒症持续时间以及多器官功能障碍综合征(multipleorgandysfunctionsyndrome,MODS)的发生率。结果UTI治疗后,脓毒症患者的血浆MDA浓度比治疗前下降,SOD活性比治疗前上升,与对照组比较,差异有统计学意义(P<0.01)。治疗组脓毒症的持续时间较对照组缩短,两组比较差异有统计学意义(P<0.01)。但两组MODS发生率比较差异无统计学意义(治疗组发生MODS3例,对照组4例)。结论乌司他丁可减轻脂质过氧化反应,清除自由基,对烧伤脓毒症有良好治疗作用。
Objective To investigate the therapeutic effect of ulinastatin on burn sepsis. Methods Forty patients with burn sepsis were randomly divided into ulinastatin (UTI) group and control group, 20 cases in each group. Both groups were treated by conventional therapy and UTI treatment. The concentration of MDA and the activity of SOD in the two groups at the time of the diagnosis of sepsis and on the seventh day after the determination were measured. The duration of sepsis and the incidence of multiple organ dysfunction syndrome (MODS) were observed and compared between the two groups. Results After UTI treatment, plasma MDA levels in septic patients decreased compared with those before treatment, and SOD activity increased compared with that before treatment. The difference was statistically significant (P <0.01) compared with the control group. The duration of sepsis in the treatment group was shorter than that in the control group, with significant difference between the two groups (P <0.01). However, there was no significant difference in the incidence of MODS between the two groups (MODS occurred in 3 cases in the treatment group and 4 cases in the control group). Conclusion Ulinastatin can reduce lipid peroxidation, scavenge free radicals and have a good therapeutic effect on burn sepsis.