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４０只豚鼠分成４组，在下切牙区龈沟分别灌注Ｇ－菌内毒素（ＬＰＳ）、Ｇ＋菌脂磷壁酸（ＬＴＡ）、龈下菌斑（ＰＬ）及生理盐水（ＮＳ），於１、２、３、６、８周分批处死观察。结果：ＮＳ对照组除１、２周牙龈出现少量炎症细胞外，未见其他异常；ＬＰＳ组１周很快出现牙龈炎症和明显骨吸收，４、５周炎症渐消退并有新骨形成；ＬＴＡ组菌斑和牙石沉积明显，而炎症与骨吸收较弱，３周即渐恢复；ＰＬ组既见菌斑牙石形成，又有炎症反应及骨吸收，持续时间较长，６、８周仍见轻度炎症。它们作用于牙周组织的不同特点，为进一步阐明牙周病的发病机理提供实验依据。
Forty guinea pigs were divided into four groups. G-bacteria lipopolysaccharide (LPS), G-lipoteichoic acid (LTA), subgingival plaque (PL) and saline (NS) 2, 3, 6, 8 weeks in batches were observed. Results: There were no abnormalities in the NS control group except for a few inflammatory cells in the gingiva of 1 and 2 weeks. Gingival inflammation and significant bone resorption occurred soon after 1 week in LPS group. Inflammation gradually subsided and new bone formed in 4 and 5 weeks. LTA Group plaque and tartar deposition, and inflammation and bone resorption is weak, gradually recovered after 3 weeks; PL group both see plaque formation, but also inflammatory response and bone resorption, a longer duration, 6,8 weeks still see Mild inflammation. They act on the different characteristics of periodontal tissue, in order to further clarify the pathogenesis of periodontal disease to provide experimental evidence.