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目的探讨辛伐他汀、低分子肝素联合氯吡格雷治疗不稳定性心绞痛(UAP)患者的临床效果。方法选取本院心血管内科收治的70例UAP患者,根据入院单双号分为试验组和对照组各35例,两组患者均给予辛伐他汀、低分子肝素及常规治疗,试验组加用氯吡格雷治疗,两组患者均连续用药4周,比较两组治疗效果。结果试验组治疗后的每周心绞痛发作次数、24 h心肌缺血发作次数、24 h心肌缺血总时间均显著的低于对照组(P<0.05)。治疗后两组患者的IL-6、hs-CRP、Hcy、NT-pro-BNP指标较本组治疗前均显著的降低(P<0.05),治疗后试验组的IL-6、hs-CRP水平显著的低于对照组(P<0.05)。试验组治疗的总有效率(88.57%)高于对照组(71.43%,P<0.05)。结论辛伐他汀、低分子肝素联合氯吡格雷治疗不稳定性心绞痛(UAP)患者具有更加显著的临床效果。
Objective To investigate the clinical effects of simvastatin, low molecular weight heparin and clopidogrel in the treatment of patients with unstable angina pectoris (UAP). Methods Seventy UAP patients admitted to our hospital were enrolled in this study. According to the hospital admission single and double numbers, 35 patients were divided into experimental group and control group. Simvastatin, low molecular weight heparin and routine treatment were given to both groups. Clopidogrel treatment, two groups of patients were treated for 4 weeks, the two groups were compared. Results The number of angina attacks per week, the number of myocardial ischemic attacks 24 h and the total myocardial ischemia 24 h after treatment were significantly lower in the experimental group than those in the control group (P <0.05). The levels of IL-6, hs-CRP, Hcy and NT-pro-BNP in the two groups after treatment were significantly lower than those before treatment (P <0.05) Significantly lower than the control group (P <0.05). The total effective rate of treatment group (88.57%) was higher than that of control group (71.43%, P <0.05). Conclusion Simvastatin, low molecular weight heparin and clopidogrel have more significant clinical effects in patients with unstable angina pectoris (UAP).