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目的 探讨高脂饮食对阿霉素肾病大鼠肾小球硬化的影响。方法 应用病理、免疫组化及分子生物学方法结合图像分析技术，观察高脂饮食对大鼠血胆固醇、尿蛋白、肾脏病理形态学改变以及肾小球系膜基质产生的影响。结果 在非肾病组及肾病组，高脂饮食大鼠的血胆固醇较标准饮食大鼠明显升高，分别为（ 2.2± 0.3） g/L vs(0.9± 0.1)g/L(P
Objective To investigate the effect of high-fat diet on glomerulosclerosis in adriamycin-induced nephropathy rats. Methods The pathological, immunohistochemical and molecular biological methods combined with image analysis techniques were used to observe the effects of high-fat diet on blood cholesterol, urinary protein, renal pathomorphology and glomerular mesangial matrix formation in rats. Results In the non-nephropathy group and the nephropathy group, the blood cholesterol of the high fat diet rats was significantly higher than that of the standard diet rats (2.2 ± 0.3 vs 0.9 ± 0.1 g / L, P