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目的观察顺尔宁联合雾化(普米克令舒和万托林)治疗儿童哮喘急性发作的临床疗效。方法选取2009年1月至2010年12月符合儿童哮喘诊断标准的哮喘急性发作患儿100例(轻、中度),随机分为两组:对照组50例,予普米克令舒1.0mg/次和万托林2.5mg/次混合后加生理盐水至3～4ml,2次/d,经氧气驱动雾化吸入;治疗组50例,在对照组用药的基础上加口服顺尔宁,疗程为10d。比较两组临床症状、体征消失时间及肺功能测定(FEV1、PEF)。结果治疗组的临床症状消失时间比对照组明显缩短(P<0.05),两组治疗前、治疗后10d比较肺功能各项指标差异有统计学意义(P<0.01)。结论顺尔宁联合雾化吸入治疗儿童哮喘急性发作,能迅速缓解临床症状,改善肺功能,具有协同作用,且用药安全性高,值得临床推广应用。
Objective To observe the clinical efficacy of combination of Salbutamol with atomization (pulmicort and wantroplin) in the treatment of acute asthma in children. Methods One hundred children (mild and moderate) with acute asthma who met diagnostic criteria for childhood asthma from January 2009 to December 2010 were randomly divided into two groups: control group (n = 50), pulmicorin 1.0 mg / Times and Wantropin 2.5mg / times mixed with saline to 3 ~ 4ml, 2 times / d, aerosol inhalation inhalation; the treatment group of 50 patients in the control group based on the medication plus oral Salbutamol, treatment For 10d. Clinical symptoms, signs of disappearance and pulmonary function test (FEV1, PEF) were compared between the two groups. Results The disappearance time of clinical symptoms in the treatment group was significantly shorter than that in the control group (P <0.05). There were significant differences in the indexes of pulmonary function between the two groups before and 10 days after treatment (P <0.01). Conclusion Combined treatment of nebulization and inhalation of salbutamol in children with acute asthma attacks can quickly relieve clinical symptoms and improve lung function, with synergistic effects, and the drug is safe and worthy of clinical application.