An experimental study of preventing and treating acute radioactive enteritis with human umbilical co

• 作 者: Rui Wang Wei Yuan Qiang Zhao Peng Song Ji Yue Shi-De Lin Ting-Bao Zhao
• 机 构: Jinan Miltary General Hospital, Shandong Province, China“,”People’s Hospital of Zhangqiu, Shandong P
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2013年12期
• 关键词: Radioactive contamination Human umbilical cord mesenchymal stem cells Acute radi

Objective:To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus to provide clinical therapeutic basis for radiation sickness.Methods:Human umbilical cord-derived mesenchymal stem cells were cultivatedin vitro and the model of acute radioactive enteritis of rats was established.Then, the umbilical cord mesenchymal stem cells were injected into the rats via tail vein.Visual and histopathological changes of the experimental rats were observed.Results:After the injection, the rats in the prevention group and treatment group had remarkably better survival status than those in the control group.The histological observations revealed that the former also had better intestinal mucosa structure, more regenerative cells and stronger proliferation activity than the latter.Conclusions:Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.