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五十年前,Euler(1935年)首先研究了前列腺素(Prostaglandin,简称 PG)制剂的生物学作用。1959年 Bergstr(?)m 第一个报道了外源性前列腺素 E_1(PGE_1)对人体的心血管效应。现就其心血管效应作一概要介绍。对血压的影响 PGE_1是一强力血管扩张剂,可使大多数血管床松弛,减低外周血管阻力、降低血压。给动物输注 PGE_1(平均剂量0.146微克/公斤/分钟)时可使平均动脉压和肺动脉压显著下降。健康男子在输注0.2～0.7微克/公斤/分钟 PGE_14～10分钟时平均血压降低24～10毫米汞柱,
Fifty years ago, Euler (1935) first studied the biological effects of prostaglandin (PG) preparations. In 1959 Bergstr (?) M first reported the cardiovascular effects of exogenous prostaglandin E_1 (PGE_1) on the human body. Now on its cardiovascular effects for a brief introduction. Impact on Blood Pressure PGE_1 is a potent vasodilator that relaxes most vascular beds and reduces peripheral vascular resistance and blood pressure. Infusion of PGE 1 into animals (mean dose 0.146 μg / kg / min) resulted in a significant decrease in mean arterial pressure and pulmonary arterial pressure. Healthy men in the infusion of 0.2 ~ 0.7 micrograms / kg PGE_14 ~ 10 minutes average blood pressure decreased 24 ~ 10 mm Hg,