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本文观察了66例肾炎患者空腹血胰升血糖素、胰岛素、C肽和血糖的改变。男46例,女20例,年龄11～71岁,平均42岁,对其中35例做了口服葡萄糖耐量试验(OGTT),观察以上四种物质血中浓度的变化。肾炎病人与53例正常人相比,结果如下:(1)肾炎病人有明显高胰升血糖素血症。肾功能愈差,胰升血糖素愈高。服葡萄糖后,胰升血糖素下降不明显。尿毒症常伴有血胰升血糖素升高,这是肾清除率下降之故;(2)空腹高胰岛素血症及糖耐量减低,提示胰岛素抗
This article observed the fasting blood of 66 patients with nephritis glucagon, insulin, C-peptide and blood glucose changes. There were 46 males and 20 females, aged from 11 to 71 years old with an average of 42 years old. Oral glucose tolerance test (OGTT) was performed on 35 of them and the changes of blood concentrations of the above four substances were observed. Nephritis patients compared with 53 normal subjects, the results are as follows: (1) nephritis patients have obvious high glucagonmia. The worse the kidney function, glucagon higher. After taking glucose, glucagon decline is not obvious. Uremia is often accompanied by elevated blood glucagon, which is the result of decreased renal clearance; (2) fasting hyperinsulinemia and impaired glucose tolerance, suggesting that insulin resistance