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结肠黑变病是以结肠固有膜吞噬细胞内棕黄色素沉着为特征的疾病。尽管长期使用蒽醌类泻剂在其形成中起主要作用,但是也可能有其他因素参与。故研究IBD伴结肠黑变病的特征,以确定其是否与使用泻剂有关。 方法:同时患结肠黑变病和IBD的病例选自1993～1996年Mayo医院的资料。统计IBD和结肠黑变病的诊断日期、内镜检查时肉眼下结肠黑变病和IBD分布的范围、IBD类型和持续时间、所用的药物(包括泻剂)。大体改变依据结肠粘膜变色,组织学改变要求两位病理医生对结肠黑变病和IBD的分布和严重程度达成一致。黑变病按固有膜吞噬细胞内棕黄色素颗
Colitis mellitus is a disease characterized by brown pigmentation within the phagocyte of the colon. Although long-term use of anthraquinone laxatives plays a major role in its formation, other factors may also be involved. Therefore, the study of IBD with colorectal melanosis characteristics to determine whether it is associated with the use of laxatives. Methods: Both cases of colitis and IBD were selected from Mayo Hospital from 1993 to 1996. The date of diagnosis of IBD and melanosis, the range of sub-colon melanosis and IBD distribution at endoscopy, the type and duration of IBD, the medication used (including laxatives). General changes based on discoloration of colonic mucosa, histological changes require two pathologists on the distribution of melanosis and IBD and reached an agreement on the severity. Melanosis by inherent membrane phagocytic cells brown pigment particles