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目的:探讨多发性骨髓瘤的临床特征及诊断措施。方法:对我院47例多发性骨髓瘤患者的临床一般资料、实验室检查进行回顾性分析。结果:IgG-κ轻链型占29.8%(14/47);IgG-λ轻链型占31.9%(15/47);IgA-κ轻链型占6.4%(3/47);IgA-λ轻链型占12.8%(6/47);IgM、IgD型各占2.1%(1/47);单纯κ轻链型占6.4%(3/47);单纯λ轻链型占6.4%(3/47);不分泌型占2.1%(1/47);κ/λ型之比为0.81/1。结论:多发性骨髓瘤临床表现多样,对可疑患者进行全面系统的检查,尤其是血清免疫固定电泳、免疫球蛋白测定、X线检查及多部位骨髓穿刺检查是确诊的重要手段,对早期诊断、判断分型以及指导治疗、提高患者生存期有重要意义。
Objective: To investigate the clinical features and diagnosis of multiple myeloma. Methods: The general clinical data and laboratory tests of 47 patients with multiple myeloma in our hospital were analyzed retrospectively. Results: IgG-κ light chain accounted for 29.8% (14/47); IgG-λ light chain accounted for 31.9% (15/47); IgA-κ light chain accounted for 6.4% (3/47) Light chain accounted for 12.8% (6/47); IgM, IgD accounted for 2.1% (1/47); simple κ light chain accounted for 6.4% (3/47); simple λ light chain accounted for 6.4% (3 / 47); nonsecretion accounted for 2.1% (1/47); κ / λ ratio of 0.81 / 1. Conclusion: The clinical manifestations of multiple myeloma are diverse, and the suspicious patients can be examined comprehensively and systematically, especially the serum immunoelectrophoresis, immunoglobulin, X-ray and multi-site bone marrow aspirations. It is an important method to confirm the diagnosis, To determine the type and guide treatment, improve patient survival is important.