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探讨了慢性低压低氧对大鼠肺血管反应性的影响 ,以及前列腺素在其中的作用。结果表明 :1离体肺动脉在急性低氧时先收缩后舒张。大鼠经慢性低氧 15 d、 30 d后离体肺动脉对急性低氧所致收缩反应 (+Δ TIH)较各自对照组均明显降低 [(10 .11± 9.5 6 ) mg、 (14.5 7± 10 .0 2 ) m g Vs (2 7.15± 12 .0 9) mg、 (2 7.86± 13.0 7) mg,P<0 .0 1) ];舒张反应 (-Δ TIH)较各自对照组均明显增强 [(14.18± 5 .14) mg、 (2 6 .35± 11.74) m g Vs (9.39± 7.12 ) mg、 (8.99± 7.32 ) mg]。 2慢性低氧 15 d、 30 d后单位重量肺血管对高钾收缩反应 (ΔTK0 )为 [(10 5 .4± 32 .2 ) m g、 (113.9±2 8.3) m g],分别低于各自对照组 [(132 .7± 30 .3) m g、 (133.1± 34 .2 ) mg]。 3消炎痛可增强低氧性肺血管收缩反应 ,慢性低氧 30 d组增强百分比为 (148.87± 5 7.0 8) % ,明显高于其对照组 (5 9.0 2± 2 4.5 2 ) % ,P<0 .0 1。提示 :慢性低氧降低肺血管反应性可能是由于肺血管平滑肌的收缩性降低以及前列腺素对 HPV的调节作用增强所致。
The effects of chronic hypobaric hypoxia on pulmonary vascular reactivity in rats and the role of prostaglandins in them were explored. The results showed that: 1 isolated pulmonary artery contraction in the first acute hypoxia after diastolic. After acute hypoxia for 15 days and 30 days, the contractile responses to acute hypoxia (+ Δ TIH) in isolated pulmonary arteries were significantly lower than those in the control groups [(10.11 ± 9.56) mg and (14.57 ± 10 .0 2) mg Vs (2 7.15 ± 12 .0 9) mg, (2 7.86 ± 13.0 7) mg, P <0.01); diastolic response (-Δ TIH) [(14.18 ± 5 .14) mg, (26.35 ± 11.74) mg Vs (9.39 ± 7.12) mg, (8.99 ± 7.32) mg]. 2 Chronic hypoxia 15 d, 30 d after the weight of the pulmonary peritoneal hyperkalemic response (ΔTK0) was (105.4 ± 32.2 mg, (113.9 ± 2.83) mg], respectively, lower than the respective control Group [(132.7 ± 30.3) mg, (133.1 ± 34.2) mg]. 3 Indomethacin can enhance hypoxic pulmonary vasoconstriction, the percentage of enhancement in chronic hypoxia 30 d group was (148.87 ± 5 7.08)%, which was significantly higher than that in control group (5 9.0 2 ± 2. 4.5 2)%, P < 0 .0 1. Tip: Chronic hypoxia reduces pulmonary vascular reactivity may be due to decreased pulmonary vascular smooth muscle contraction and prostaglandin HPV on the regulation of the role of increased.