Quantification of atorvastatin in human plasma by liquid chromatography tandem mass spectrometry and

• 作 者: Yahdiana Harahap Santi Purnasa
• 机 构: LaboratoryofBioavailabilityandBioequivalence
• 出 处: 亚洲药物制剂科学(英文)
• 发表日期: 2016年1期
• 关键词: ATORVASTATIN SIMVASTATIN LC-MS/MS

Atorvastatin, a chemical ([R-(R*, R*)]-2-(4-fluorophenyl)-b,ddihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]1 H-pyrole-1-heptanoic acid), is a synthetic HMG-Co A (3-hydroxy-3-methylglutaryl-coenzyme A)reductase inhibitor. It has been shown