论文部分内容阅读
对家兔作钾离子透入法测痛,腹腔注射东莨菪碱4mg/kg,给药后30分钟痛阈提高49％。静脉注射同样剂量的东莨菪碱,给药后20分钟痛阈提高37％。侧脑室注射5 μg/只后20分钟痛阈提高53％。这些结果表明东莨菪碱有一定强度的镇痛作用。与度冷丁(60 mg/kg腹腔注射)合用痛阈提高147％,而单用度冷丁病阈升高93％,提示两药合用有协同作用。 对小白鼠用热板法测痛,腹腔注射东莨菪碱1.25 mg/kg,给药后15分钟病阈提高62％。与小剂量度冷丁(10 mg/kg腹腔注射)合用,给药后15分钟痛阈提高126％,而单用小剂量度冷丁痛阈仅提高23％。这些与用家兔实验的结果一致。 给家兔侧脑室注射去甲肾上腺素20 μg/只后,10分钟时痛阈下降46％,并能减弱度冷丁的镇痛作用。东莨菪碱与去甲肾上腺素合用,则能拮抗后者的抗镇痛作用。因此推测东莨菪碱的镇痛和加强度冷丁镇痛的作用,可能与其抗去甲肾上腺素的作用有关。
Rabbits were infiltrated with potassium to measure pain, scopolamine intraperitoneal injection of 4mg / kg, 30 minutes after administration of pain threshold increased by 49%. The same dose of scopolamine was injected intravenously and the pain threshold was increased by 37% 20 minutes after administration. Pain threshold increased 53% at 20 minutes after intracerebroventricular injection of 5 μg / dose. These results show that scopolamine has a certain degree of analgesic effect. And valsartan (60 mg / kg intraperitoneal injection) combined pain threshold increased 147%, while the single use of cold dying sickness threshold increased 93%, suggesting a synergistic combination of the two drugs. The mice were anesthetized with the hot plate method and injected intraperitoneally with scopolamine 1.25 mg / kg. The threshold of attack increased by 62% 15 minutes after the administration. With a small dose of cold Ding (10 mg / kg intraperitoneal injection) combined 15 minutes after administration of pain threshold increased by 126%, and only a small dose of cold pain threshold increased by only 23%. These are consistent with the experimental results of rabbits. After injecting 20 μg / norepinephrine into the lateral ventricle of rabbits, the pain threshold decreased by 46% at 10 minutes, and the analgesic effect of chilling could be weakened. Scopolamine combined with norepinephrine, can antagonize the latter anti-analgesic effect. Therefore speculated that the analgesic effect of scopolamine and analgesic effect of cold Ding may be related to its anti-norepinephrine role.