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目的探讨红细胞平均体积(MCV)和红细胞平均血红蛋白量(MCH)对不同类型地中海贫血的筛查价值。方法回顾性分析251例地中海贫血患者及50例正常已婚夫妇的MCV、MCH。结果不同类型地中海贫血的MCV、MCH均降低,和正常对照组比较差异有显著性(P<0.01),静止型地贫的MCV、MCH与其他类型地中海贫血比较差异有显著性(P<0.01),MCV<80fl、MCH<27pg的发生率分别为55.56%、16.67%,与其他类型地中海贫血MCV<80fl、MCH<27pg的发生率比较差异有显著性(P<0.01)。结论利用MCV、MCH可进行地中海贫血的筛查,其中MCV的筛查价值高于MCH;MCV和MCH降低的,极可能是地中海贫血,MCV和MCH正常不能除外静止型地贫。
Objective To investigate the screening value of different types of thalassemia for mean corpuscular volume (MCV) and mean hemoglobin (MCH). Methods Retrospective analysis of 251 cases of thalassemia and 50 normal married couples MCV, MCH. Results The MCV and MCH of different types of thalassemia were lower than those of the normal control group (P <0.01). The MCV and MCH of resting thalassemia were significantly different from those of other types of thalassemia (P <0.01) , MCV <80fl and MCH <27pg were 55.56% and 16.67%, respectively. The incidence of MCV <80fl and MCH <27pg was significantly different from other types of thalassemia patients (P <0.01). Conclusion MCV and MCH can be used to screen for thalassemia. The screening value of MCV is higher than that of MCH. The reduction of MCV and MCH is most likely due to thalassemia. MCV and MCH can not be excluded except thalassemia.