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目的探讨合并非酒精性脂肪肝(NAFLD)的2型糖尿病(T2DM)患者血清铁蛋白(SF)水平与氧化应激、胰岛素抵抗的关系。方法对44例T2DM患者(A组,22例,无NAFLD;B组,22例,合并NAFLD)和健康体检者(C组,22例)检测了血总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、SF和丙二醛(MDA)水平,并采用稳态模型评估胰岛素抵抗指数(HOMA-IR)。结果 A组和B组的SF、MDA水平高于C组(P<0.01),B组SF、MDA水平显著高于A组(P<0.01)。SF水平与病程、体重指数、TC、TG、HbA1c、FPG、FINS、HOMA-IR、MDA水平呈正相关。结论 T2DM合并NAFLD患者体内铁超负荷;氧化应激、胰岛素抵抗可能参与了NAFLD的发生发展。
Objective To investigate the relationship between serum ferritin (SF) and oxidative stress and insulin resistance in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). Methods Serum total cholesterol (TC), triglyceride (TG) and total cholesterol (TC) were measured in 44 patients with T2DM (group A, n = 22, without NAFLD; group B, n = 22 with NAFLD) and healthy subjects (group C, n = 22) (FPG), fasting insulin (FINS), HbA1c, SF and malondialdehyde (MDA) levels were measured. The insulin resistance index (HOMA-IR) was assessed by a steady-state model. Results The levels of SF and MDA in group A and B were higher than those in group C (P <0.01). The levels of SF and MDA in group B were significantly higher than those in group A (P <0.01). The level of SF was positively correlated with the course of disease, body mass index, TC, TG, HbA1c, FPG, FINS, HOMA-IR and MDA. Conclusion T2DM with NAFLD patients with iron overload; oxidative stress, insulin resistance may be involved in the occurrence and development of NAFLD.