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丙氟哌酸(Ciprofloxacin)是活性最强的氟代喹诺酮类药物之一,体外抗菌试验表明,对分枝杆菌、脊髓病毒属、衣原菌属等需氧菌有强的活性,但抗厌氧菌活性呈中等强度(在1μg/ml下,抑制4%细菌生长),并且这种活性随培养基不同(在Wilking-Chalgrem培养基上抗菌活性强于Brucella培养基)和pH改变(pH为7时抗菌活性强于6)而变化,为提高其抗厌氧菌活性,加拿大温哥华总医院研究人员将丙氟哌酸分别与氯林霉素、甲硝唑(Metronidazole)、头孢西丁、美洛西林、头孢噻肟等按一定比例联合。从临床分离了代表六个主要厌氧菌属耐喹诺酮类的598株厌氧菌,用Wilkins-Chalgren培养基的琼脂稀释法试验证明:丙氟哌酸与头
Ciprofloxacin (Ciprofloxacin) is one of the most active fluoroquinolones. In vitro antibacterial tests show that it has strong activity against aerobic bacteria such as Mycobacterium, Mycoplasma and Clostridium, but its anti-anaerobic activity (4% bacterial growth inhibition at 1 μg / ml) and this activity varies with medium (stronger antimicrobial activity on Brucella medium on Wilking-Chalgrem medium) and pH change (antimicrobial activity at pH 7 Activity stronger than 6) changes, in order to improve its anti-anaerobic activity, the Canadian Vancouver General Hospital researchers will be propylene piperacillin, clindamycin, metronidazole (Metronidazole), cefoxitin, mezlocillin, cefotaxime By a certain percentage of joint. 598 strains of anaerobic bacteria, representative of the six major anaerobic quinolones, were isolated from clinical trials using an agar dilution assay in Wilkins-Chalgren medium demonstrating that propofol and fentanyl