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[目的]研究结直肠癌患者血清中组织多肽特异性抗原(TPS)、CA199和CEA水平及结直肠癌患者根治术前后两者水平的变化,为结直肠癌的临床诊断、预后提供参考。[方法]用ELISA法检测血清TPS水平;用ECL法检测血清CA199和CEA水平。[结果]结直肠癌患者的血清TPS、CA199和CEA水平与结直肠良性疾病和正常人比较有显著性差异(P<0.001),且随TNM分期增加而升高。手术治疗后三种肿瘤标志物水平明显下降,而术后复发患者的水平则明显升高。各种组合检测中,以TPS+CA199+CEA组合的敏感性和约登指数最高。[结论]血清TPS、CA199和CEA均可作为结直肠癌诊断、预后的临床指标,三者联合检测可提高结直肠癌的临床应用价值。
[Objective] To study the changes of serum Tissue Polypeptide Specific Antigen (TPS), CA199 and CEA in patients with colorectal cancer and the changes of both before and after radical operation in patients with colorectal cancer, and to provide reference for the clinical diagnosis and prognosis of colorectal cancer. [Methods] Serum TPS levels were detected by ELISA. Serum CA199 and CEA levels were measured by ECL. [Results] The serum levels of TPS, CA199 and CEA in patients with colorectal cancer were significantly different from those in patients with benign colorectal diseases and normal controls (P <0.001), and increased with the TNM staging. The levels of three tumor markers decreased significantly after surgery, while the levels of postoperative recurrence were significantly higher. In all combinations, the combination of TPS + CA199 + CEA has the highest sensitivity and Youden index. [Conclusion] Serum TPS, CA199 and CEA can be used as clinical indicators of diagnosis and prognosis of colorectal cancer. The combination of the three tests can improve the clinical value of colorectal cancer.