论文部分内容阅读
本文研究了低剂量γ射线与噪声对豚鼠听觉的复合效应。实验动物分为６组：正常对照组、噪声组、照射组（１，２）和复合暴露组（１，２）。复合１组日照射线剂量率为０．００７５Ｇｙ／２ｈ，累计剂量０．３０Ｇｙ。复合２组为０．０３７５Ｇｙ／２ｈ，累计剂量１．５０Ｇｙ。复合１，２组暴露噪声均为９０±２ｄＢＡ。射线与噪声每天全身同时作用２ｈ，每周连续作用５ｄ，持续２个月。噪声与照射组的暴露条件分别与复合组相同。暴露结束后４８ｈ测定各组听阈，计算听阈偏移。结果表明，两低剂量照射组的听阈，分别比正常对照组高３．６和４．０ｄＢ（Ｐ＜０．０５）。统计处理表明，复合１组的噪声与γ射线相互作用显著（Ｐ＜０．０５），对听觉损伤相互拮抗，复合２组两因素相互作用不显著，但复合效应仍倾向拮抗。
This article studies the combined effect of low-dose gamma-rays and noise on auditory guinea pigs. The experimental animals were divided into 6 groups: normal control group, noise group, irradiation group (1, 2) and compound exposure group (1, 2). Compound 1 sunshine radiation dose rate of 0.0075Gy / 2h, the cumulative dose of 0.30Gy. Compound 2 group was 0.0375Gy / 2h, the cumulative dose of 1.50Gy. Compound 1 and 2 exposure noise were 90 ± 2dBA. Radiation and noise every day the body at the same time role 2h, continuous 5d weekly for 2 months. The exposure conditions of noise and irradiation group were the same as the composite group. 48h after exposure, the threshold of each group was measured, and the threshold shift was calculated. The results showed that the hearing threshold of the two low-dose irradiation groups were 3.6 and 4.0 dB higher than that of the normal control group (P <0.05). Statistical analysis showed that there was a significant (P <0.05) interaction between noise and γ-ray in composite group 1 and antagonistic auditory impairment. The two-factor interaction in compound 2 group was not significant, but the compound effect tended to be antagonistic.