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为增强人参皂甙在体内的靶向性以提高其抗癌疗效，同时提高其生物利用度，对人参皂甙脂质体（ＧＳＬ）的制备进行了初步研究。采用薄膜分散法制备了６８Ｌ并对其理化性质进行了考察。显微及电镜鉴别结果显示，所制得的ＧＳＬ以复层脂质体为主，单层脂质体少数，碎片很少；采用标准品对照法测得其包封率为５１．４％；用热差分析法测相变温度为７０Ｃ；使用多功能图象仪测得粒径大多在０．７～１．２μｍ之间。研究结果表明，用所报道的薄膜分散法制备的ＧＳＬ有较理想的包装率和较适宜的粒径范围，人参皂甙完全可能做成载药脂质体。这一结论对人参皂甙的进一步开发和利用，尤其是在人参皂甙对肿瘤的治疗方面将有十分重要的作用。
In order to enhance the targeting of ginsenosides in vivo to improve its anticancer efficacy and to improve its bioavailability, the preparation of ginsenoside liposomes (GSL) was studied. 68L was prepared by thin film dispersion method and its physical and chemical properties were investigated. Microscopic and electron microscopic examination showed that the GSL was mainly composed of multilamellar liposomes with few single liposomes and few fragments. The entrapment efficiency of the prepared GSL was 51.4% by standard comparison method. Measured by thermal analysis of the phase transition temperature is 70C; the use of multi-function image analyzer measured particle size mostly between 0.7 ~ 1.2μm. The results show that GSL prepared by the reported film dispersion method has a better packing ratio and a more suitable particle size range, and ginsenosides is entirely possible to be a drug-loaded liposome. This conclusion on the further development and utilization of ginsenosides, especially in the treatment of ginsenosides will have a very important role.