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目的:观察喉鳞状细胞癌组织中凋亡抑制因子Livin的表达及与碱性成纤维细胞生长因子(bFGF)的关系,探讨Livin在喉鳞状细胞癌发病中的作用机制。方法:收集喉鳞状细胞癌标本41例(其中有淋巴结转移者11例)和正常软腭黏膜组织20例,用免疫组织化学染色法检测Livin和bFGF的表达情况。结果:喉鳞状细胞癌中Livin表达阳性率为70.73%(29/41),显著高于正常软腭黏膜组织(呈阴性表达);Livin在喉鳞状细胞癌中阳性率与淋巴结转移有关(P<0.05),未见与组织分化、临床分期和年龄相关(均P>0.05);Livin和bFGF在喉癌中的表达呈显著正相关。结论:Livin在喉鳞状细胞癌组织中的高度表达在喉鳞状细胞癌的发展中可能起重要作用,并可能和bFGF有协同作用。
Objective: To investigate the relationship between the expression of Livin and bFGF in laryngeal squamous cell carcinoma (LSCC) and to explore the mechanism of Livin in the pathogenesis of laryngeal squamous cell carcinoma. Methods: Totally 41 cases of laryngeal squamous cell carcinoma (including 11 cases of lymph node metastasis) and 20 cases of normal soft palate mucosa were collected. The expression of Livin and bFGF was detected by immunohistochemical staining. Results: The positive rate of Livin in laryngeal squamous cell carcinoma was 70.73% (29/41), which was significantly higher than that in normal soft palate mucosa (negative). The positive rate of Livin in laryngeal squamous cell carcinoma was related to lymph node metastasis <0.05). There was no significant correlation between the expression of Livin and bFGF in laryngeal carcinoma (P> 0.05). Conclusion: The high expression of Livin in laryngeal squamous cell carcinoma may play an important role in the development of laryngeal squamous cell carcinoma and may have a synergistic effect with bFGF.