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硬皮病又称系统性硬化,以局限性或弥漫性皮肤增厚和纤维化为特征。此病可以引起多系统损害,常伴有肾脏受累,其中硬皮病肾危象(SRC)最受人关注。尽管在血管紧张素转换酶抑制剂(ACEI)广泛应用后发病率已有明显下降,但一旦发生SRC,致死致残率居高不下[1]。为进一步了解其临床特征,以更好地防治疾病,我们对本院近5年收治的5例SRC患者进行了回顾性分析,现报道如下。
Scleroderma, also known as systemic sclerosis, is characterized by localized or diffuse skin thickening and fibrosis. The disease can cause multiple system damage, often accompanied by kidney involvement, including scleroderma kidney crisis (SRC) the most concern. Although the incidence of angiotensin converting enzyme inhibitor (ACEI) has dropped significantly after its widespread use, the rate of lethal morbidity is high in the presence of SRC [1]. To further understand its clinical features in order to better prevent and cure diseases, we conducted a retrospective analysis of 5 SRC patients admitted to our hospital in the past 5 years.