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液相色谱-质谱联用技术集液相色谱的高分离效能与质谱的高鉴定性能于一体，对研究对象有足够的灵敏度、选择性，分析快速且方便，在药学研究方面的应用日益广泛。液相色谱-质谱联用是目前最重要的分离分析方法之一，在药物成分的鉴定分析、药物代谢研究、中药指纹图谱的研究以及体内药物分析等方面发挥越来越重要的作用。“,”High performance liquid chromatography-mass spectrometry (HPLC-MS) is a new technique, which has developed very fast in the recent years. It is regarded as an important technology for many advantages such as high separating efficiency, good sensitivity, wide application and strong specific. Liquid chromatography-mass spectrometry is regarded as one of the most important technology in separation and analysis. It plays an increasingly important role in analysis of drugs, metabolites, HPLC-FPS and the biopharmaceutical analysis.