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目的:观察银杏达莫注射液联合奥扎格雷纳治疗急性脑梗死的临床疗效。方法:采用随机数字表法将70例患者随机分为对照组及治疗组,每组各35例,两组均采用奥扎格雷纳并配合常规治疗。在此基础上,对照组静脉输注复方丹参注射液;治疗组静脉输注银杏达莫注射液。15天为1个疗程。1个疗程后检测血液流变学各项指标、血脂变化以及血常规、肝肾功能情况;2个疗程后评定两组病例临床疗效、行神经功能缺损评分。结果:(1)临床疗效:治疗组基本痊愈9例、显著进步12例、进步11例、无变化2例、恶化1例,总有效率91.4%;对照组基本痊愈5例、显著进步9例、进步11例、无变化7例、恶化3例,总有效率71.4%(;2)血液流变学指标检测:4项指标较治疗前均有明显改善,且治疗组又明显优于对照组(P<0.05)(;3)神经功能缺损程度评分:治疗组评分明显优于对照组,差异有显著意义(P<0.05)。结论:银杏达莫注射液联合奥扎格雷纳治疗急性脑梗死疗效确切,且无明显副作用,值得进一步研究和推广。
Objective: To observe the clinical efficacy of Yinxingdamo injection combined with Ozagrenal in the treatment of acute cerebral infarction. Methods: Seventy patients were randomly divided into control group and treatment group using random number table. Each group had 35 patients. Ozagrel and conventional treatment were used in both groups. On this basis, the control group intravenous infusion of compound Salvia injection; the treatment group intravenous infusion of gingko Damo injection. 15 days for a course of treatment. After 1 course of treatment, various indexes of hemorheology, changes of blood lipids, blood routine and liver and renal function were detected. After two courses of treatment, the clinical curative effect of two groups were evaluated and the neurological deficit score was evaluated. Results: (1) Clinical curative effect: The treatment group basically recovered in 9 cases, significant improvement in 12 cases, advanced in 11 cases, no change in 2 cases, deterioration in 1 case, the total effective rate was 91.4%; control group basically recovered in 5 cases, significantly improved in 9 cases , Improvement in 11 cases, no change in 7 cases, worsening in 3 cases, the total effective rate was 71.4% (; 2) hemorheology index detection: four indicators were significantly improved than before treatment, and the treatment group was significantly better than the control group (P <0.05) (; 3) Neurological deficit scores: The treatment group score was significantly better than the control group, the difference was significant (P <0.05). Conclusion: Yinxingdamo injection combined with Ozagrenal in the treatment of acute cerebral infarction is effective and has no obvious side effects, which deserves further study and promotion.