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目的比较血管腔内、外给硝基精氨酸对电刺激所致大鼠肠系膜动脉灌注压的影响。方法应用灌流离体血管方法，测定肠系膜动脉灌注压变化。结果电刺激引起大鼠肠系膜动脉灌注压明显升高，血管腔内、外给ＮＯ合酶抑制剂Ｌ－硝基精氨酸（Ｌ－ＮＡ）均明显增强上述灌注压升高反应，此１９９８－０１－０８收稿，１９９８－０３－２０修回＊河北省自然科学基金资助课题，Ｎｏ３９４２５１作者简介：张建新，男，４４岁，医学博士（日本），研究员，药理研究室副主任增强作用可被ＮＯ供体－Ｌ精氨酸阻断。血管腔内、外给Ｌ－ＮＡ不改变基础灌注压而且对外源性去甲肾上腺素的作用也无明显影响。结论静脉注射ＮＯ合酶抑制剂不仅可直接作用于内皮，而且也可透过内皮、平滑肌作用于外周血管神经末梢，减少ＮＯ合成进而增强肾上腺素能神经刺激所致的收缩血管反应。
Objective To compare the effect of nitroglycerine on mesenteric arterial perfusion pressure induced by electrical stimulation in and out of blood vessels. Methods The isolated perfused blood vessels were used to measure the change of mesenteric artery perfusion pressure. Results Electrical stimulation significantly increased the mesenteric artery perfusion pressure in rats. L-NA synthase (L-NA) 01-08 Received, 1998-03-20 Revised * Natural Science Foundation of Hebei Province, No. 394251 About the author: Zhang Jianxin, male, 44 years old, MD, Researcher, Deputy Director of Pharmacology Research Lab. NO donor-L arginine block. Intravascular and exogenous administration of L-NA did not change basal perfusion pressure and had no significant effect on exogenous norepinephrine. Conclusion Intravenous injection of NO synthase inhibitor can not only act directly on the endothelium, but also act on the peripheral nerve endothelium via the endothelium and smooth muscle to decrease NO synthesis and enhance the vasoconstrictive response to adrenergic nerve stimulation.