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目的观察含去甲氧柔红霉素的联合化疗方案治疗成人初发急性淋巴细胞白血病的疗效和不良反应。方法15例成人初发急性淋巴细胞白血病患者均给予VICP方案(长春新碱2mg/d,第1,8,15,21天;IDA10mg/d,第1～3天,第15～17天;环磷酰胺600mg/d,第1,15天,第22～28天;泼尼松40～60mg/d,第1～28天)。结果15例患者中,第1疗程获CR12例,CR率80%;PR1例,总有效率86.7%;NR2例。结论含去甲氧柔红霉素的联合化疗方案治疗成人初发急性淋巴细胞白血病疗效好,不良反应轻。
Objective To observe the curative effect and adverse reactions of daunorubicin combined with chemotherapy in the treatment of adult acute lymphoblastic leukemia. Methods Fifteen adult patients with acute lymphoblastic leukemia were given VICP regimen (vincristine 2 mg / day, days 1, 8, 15 and 21), IDA 10 mg / d, days 1 to 3, days 15 to 17, Phosphamide 600mg / d, the first 15 days, the first 22 to 28 days; prednisone 40 ~ 60mg / d, the 1st to 28 days). Results Of 15 patients, the first course of treatment was CR12 cases, CR rate was 80%; PR1 cases, the total efficiency of 86.7%; NR2 cases. Conclusion Combined chemotherapy with deoxyribosidase is effective in treating acute lymphoblastic leukemia in adults with mild adverse reactions.