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目的探讨原发性输卵管癌的临床病理特征及鉴别诊断。方法收集4例原发性输卵管癌的临床病理资料,并结合文献对该肿瘤的临床病理学特征、诊断与鉴别诊断进行讨论。结果 4例原发性输卵管癌发病平均年龄55岁,主要表现为阴道排液、流血、腹痛、盆腔包块。大体上肿物位于输卵管壶腹部,囊实性;镜下见输卵管黏膜上皮被肿瘤细胞取代,瘤细胞形态多样,核染色深,异型性明显,核分裂像多见。肿瘤细胞排列成腺泡状、乳头状结构。免疫组化示CA125(+)、P53(+)、CK(+)、ER(+)、PR(±)。结论原发性输卵管癌是一种罕见的恶性肿瘤,起源于输卵管黏膜上皮,多为浆液性腺癌,诊断应注意与转移性输卵管癌的鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of primary fallopian tube cancer. Methods The clinicopathological data of 4 patients with primary fallopian tube cancer were collected, and the clinicopathological characteristics, diagnosis and differential diagnosis of this tumor were discussed in combination with the literature. Results The average incidence of primary fallopian tube cancer was 55 years. The main manifestations were vaginal discharge, bleeding, abdominal pain and pelvic mass. In general, the tumor is located in the ampulla of the fallopian tube, cystic solidity; see the tubal mucosa epithelium was replaced by tumor cells microscopy, tumor cells varied in shape, nuclear staining, obvious atypia, mitotic common. Tumor cells arranged in alveolar, papillary structures. Immunohistochemistry showed CA125 (+), P53 (+), CK (+), ER (+), PR (±). Conclusions Primary fallopian tube carcinoma is a rare malignant tumor originated from tubal mucosa epithelium, mostly serous adenocarcinoma, the diagnosis should be noted with the identification of metastatic fallopian tube cancer.