论文部分内容阅读
目的研究分析放射治疗同步TNF(紫杉醇+氟尿嘧啶+奈达铂)方案治疗晚期鼻咽癌的疗效和毒副反应。方法 136例晚期鼻咽癌患者随机分为治疗组68例(放射治疗同步TNF方案化疗)和对照组(单纯放射治疗)68例。治疗组在放射治疗的第1、4周分别给予TNF方案化疗和放射治疗结束后给予2个周期TNF方案化疗。结果研究结果表明:治疗组的近期疗效为:治疗组有效率为97.01%(66/68),对照组有效率为76.47%(52/68),两组有统计学差异(P<0.05)。治疗组1、3年生存率为94.12%和85.29%,对照组1、3年生存率为70.59%和47.06%,差异有统计学意义(P<0.05)。治疗组骨髓抑制、消化道反应发生率为32.35%、36.76%,对照组骨髓抑制、消化道反应发生率为20.59%、23.53%,治疗组骨髓抑制及消化道反应虽然较对照组高,但和对照组比较无统计学差异。结论放射治疗同步TNF方案化疗能提高晚期鼻咽癌的疗效且不增加不良反应。
Objective To study the efficacy and side effects of concurrent radiotherapy (paclitaxel + fluorouracil + nedaplatin) regimen in the treatment of advanced nasopharyngeal carcinoma. Methods One hundred and sixty - six patients with advanced nasopharyngeal carcinoma were randomly divided into treatment group (n = 68) and radiation control group (n = 68). In the first and the forth week of radiotherapy, the treatment group were given TNF regimen chemotherapy and two cycles of TNF regimen after radiotherapy. Results The results showed that the short-term curative effect of the treatment group was 97.01% (66/68) in the treatment group and 76.47% (52/68) in the control group, with significant difference between the two groups (P <0.05). The 1-year and 3-year survival rates of the treatment group were 94.12% and 85.29%, respectively. The 1-year and 3-year survival rates of the control group were 70.59% and 47.06%, respectively. The difference was statistically significant (P <0.05). The incidence of myelosuppression and gastrointestinal reaction in treatment group was 32.35% and 36.76% respectively. The incidence of bone marrow suppression and gastrointestinal reaction in control group was 20.59% and 23.53% respectively. The bone marrow suppression and digestive tract reaction in treatment group were higher than those in control group There was no significant difference in the control group. Conclusion Radiation therapy with concurrent TNF regimen can improve the efficacy of advanced nasopharyngeal carcinoma without increasing adverse reactions.