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分泌型IgA(SIgA)具有明显的抗病毒、抗菌和抗毒素活性,阻止细菌向粘膜表面粘着,使侵犯粘膜的毒素失去毒力,是局部免疫的第一道防线。慢性支气管炎长期迁延,支气管粘膜的假复层柱状上皮改造为复层扁平上皮,丧失合成SIgA 的能力。作者研究慢性支气管炎时支气管粘膜SIgA 的变化,检查30例病人,年龄20～60岁,从右肺中叶支气管取活检材料,制半薄切片,用直接和间接免疫组织化学反应检查SIgA 定位。慢性炎症时支气管上皮发生改造,起初为过度分泌期,杯状细胞增多。随着炎症加
Secretory IgA (SIgA) has obvious antiviral, antibacterial and anti-toxin activity, prevent bacterial adhesion to the mucosal surface, the mucosal toxins lose virulence, is the first line of defense of local immunity. Long-term chronic bronchitis, bronchial mucosa pseudostratified columnar epithelium transformed into stratified squamous epithelium, the loss of the ability to synthesize SIgA. The authors studied bronchial mucosa SIgA changes in patients with chronic bronchitis, examining 30 patients, aged 20 to 60 years, from the right middle lung bronchial biopsy material, semi-thin sections, direct and indirect immunohistochemical examination of SIgA localization. Bronchial epithelial transformation occurs when chronic inflammation, initially for the excessive secretion of goblet cells. With inflammation plus