论文部分内容阅读
中国药典1977年版对盐酸丁卡因的含量测定只收载了对原料药的非水溶液滴定法。目前对其制剂常采用双相滴定的中和法、银量法、萃取酸碱法、四苯硼盐重量法、紫外分光光度法等。上述方法中,中和法、银量法因盐酸丁卡因原料中可能带有游离的盐酸,并且在配制注射液时需调节pH 及用氯化钠调节渗透压,故对滴定都有影响;萃取酸碱法、四苯硼盐重量法操作繁琐、费时。本文介绍一种适合医院药房对盐酸丁卡因注射液含量测定的方法——亚硝酸内指示剂法(仲胺亚硝基化法).
Chinese Pharmacopoeia 1977 edition of tetracaine hydrochloride content is only contained in the non-aqueous solution titration of raw materials. At present, its preparation often uses two-phase titration of the neutralization method, the amount of silver method, extraction of acid-base method, tetraphenylborate gravimetric method, UV spectrophotometry. In the above method, the neutralization method and the silver method may have the effect of titration because of the possible hydrochloric acid contained in the raw tetracaine hydrochloride and the adjustment of the pH and the osmotic pressure when sodium chloride is used in the preparation of the injection. Acid extraction method, tetraphenylborate weight method cumbersome, time-consuming. This article describes a suitable hospital pharmacy tetracaine hydrochloride injection method - nitrite internal indicator method (secondary amine nitrosation).